Amniotic products are ideal for cosmetic applications because of their high concentration of multiple growth factors involved in tissue growth and regeneration. The avascular, low immunogenic, anti-inflammatory properties of amniotic membrane make it valuable for clinical research or further manufacturing purposes in a wide range of regenerative or aesthetic applications.
Amniotic grafting products are used to heal acute and chronic wounds, burns, ulcers, corneal injuries, and numerous orthopedic applications. Although they have not yet been used extensively in cosmetic surgery, their success in these other applications suggests that there are many ways in which these products will enhance results and speed healing times for cosmetic patients.
Our products are derived from human amniotic membrane that is obtained from the placenta. The layers of the placenta are rich in collagen types I, III, IV, V, and VII, contain structural matrixes (ECM) like fibronectin, laminins, proteoglycans and glycosaminoglycans, and have high concentrations of growth factors. These attributes provide an excellent structure for skin cellular migration and proliferation. Because the innermost amniotic layer of the placenta is in contact with the fetus throughout its developmental stages, grafts obtained from this layer contain a myriad of growth factors, cytokines, and extracellular matrix proteins that are biologically beneficial for tissue regeneration.
Besides suppressing pro-inflammatory cytokines, amnion secretes large amounts of B-defensins, SLPIs (secretatory leukocyte proteinase inhibitor) and elafin, all of which reduce microbial activity. The human placenta from which our products are derived produces no HLA antigens (A,B,C or beta-2 microglobulin) because of a lack of viable epithelium cells, making it one of the most non-immunogenic materials.
Because of the wide medical applications of these products, their availability for aesthetics and wellness has been limited secondary to cost constraints. However, its biological properties make it ideal for use in a variety of aesthetic applications. To this end, we have worked diligently with some of the best manufacturers of these products to provide an affordable framework for clinicians to explore these products for clinical research or further manufacturing purposes.
